Livedoid vasculitis - Vasculita Livedoid
Vasculita Livedoid (Livedoid vasculitis) este o boală cutanată cronică, observată predominant la femeile tinere până la vârstă mijlocie. Un acronim folosit pentru a descrie caracteristicile sale este „Ulcere purpurice dureroase cu model reticular al extremităților inferioare” (VIOLET). Este asociată cu o serie de afecțiuni, inclusiv hipertensiune venoasă cronică și varicoze.
☆ AI Dermatology — Free Service
În rezultatele Stiftung Warentest din Germania din 2022, satisfacția consumatorilor față de ModelDerm a fost doar puțin mai mică decât în cazul consultațiilor plătite de telemedicină.
În rezultatele Stiftung Warentest din Germania din 2022, satisfacția consumatorilor față de ModelDerm a fost doar puțin mai mică decât în cazul consultațiilor plătite de telemedicină.
Poate fi însoțită de durere.
relevance score : -100.0%
ReferencesLivedoid vasculopathy este o afecțiune rară a pielii, caracterizată prin ulcere dureroase care reapar în mod constant la nivelul picioarelor.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy este o afecțiune rară a pielii care provoacă ulcere recurente la nivelul picioarelor, lăsând în urmă cicatrici palide cunoscute sub numele de atrofie blanche. Deși cauza exactă este încă neclară, se crede că creșterea coagulării sângelui (hypercoagulability) este factorul principal, inflamația jucând un rol secundar. Factorii care contribuie la coagulare includ: deficiențe ale proteinelor C și S, mutații genetice, cum ar fi factorul V Leiden, deficiență de antitrombină III, mutații ale genei protrombină și niveluri ridicate de homocisteină. În biopsii, afecțiunea arată cheaguri de sânge în interiorul vaselor, îngroșarea pereților vaselor și cicatrici. Tratamentul implică o abordare pe mai multe direcții, concentrată pe prevenirea cheagurilor de sânge cu medicamente antiplachetare, diluanţi ai sângelui și terapie fibrinolitică. Pentru această afecțiune a pielii pot fi utilizate diferite medicamente: colchicine și hydroxychloroquine, vasodilatatoare, imunosupresoare.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy este o afecţiune rară, caracterizată prin leziuni la ambele picioare. Se consideră că formarea cheagurilor de sânge în vasele mici este determinată de coagularea excesivă și de fibrinoliza scăzută, alături de deteriorarea endotelului vascular. Boala este mai frecventă la femei, în special între 15 și 50 de ani. Renunțarea la fumat, îngrijirea adecvată a rănilor și utilizarea medicamentelor, cum ar fi anticoagulants (anticoagulante) și antiplatelet agents (antiagregante plachetare), s-au dovedit eficiente.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
